drug: zotepine
- Clinical class: atypical antipsychotic
- Chemical class: dibenzothiepine
- Action: serotonin-dopamine antagonist
- CSA schedule: none
- DEA number: none
U.S. Preparations:
- Zoleptil (Abbott Laboratories) FDA approved: not approved
Preparations Outside U.S.:
- Lodopin, Majorpin, Nipolept, Setous, Zopite
Stephen Stahl's Clinical Pearls* (Consult your physician before making any change in your treatment.)
- Most common side effects are constipation, dry mouth, insomnia, sleepiness, asthenia and weight gain.
- There is an active metabolite.
- Marketed in Japan and Europe; in clinical trials in the USA
- Blocks norepinephrine reuptake as well as SDA properties, suggesting efficacy for depressive symptoms in schizophrenia
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*Reprinted with permission from: Stahl, Stephen M Psychopharmacology of Antipsychotics Paperback 1999 Martin Dunitz, Ltd You cannot fully appreciate this book until you have seen the extraordinary illustrations of every aspect of this area of psychopharmacology and neurochemistry. Loaded with practical clinical "pearls."